Israeli universities team on organ repair research

Hebrew University, Bar-Ilan University and University of Haifa will establish a center for studying the sea anemone Nematostella, which has the ability to restore damaged body parts.

A sophisticated national center for genetically engineering the sea anemone Nematostella will be opened as part of the Israeli Ministry of Science and Technologys program to develop scientific and technological infrastructure in marine biology. The remarkable ability of this animal to regenerate its body parts could help further research into organ repair in humans.

The research will bring together Hebrew University of Jerusalem developmental biologist Dr. Uri Gat, Bar-Ilan University coral researcher Dr. Oren Levy, and Dr. Tamar Lotan, a researcher of sea anemones and jellyfish at the University of Haifa.

The Nematostella (Nematostella vectensis) is a sea anemone belonging to a large phylum of animals called Cnidarians that are among the most ancient animals on the evolutionary ladder. These animals, which include sea anemones, corals, jellyfish and hydra, have stinging cells on their tentacles through which they can devour larger creatures and pose a nuisanceand a dangerto bathers.

In order to study a particular animal, researchers must find an "animal model" that can easily be grown under laboratory conditions and studied in all stages of its life cycle. To do this scientists use small animals that grow and multiply quickly and whose genetic code is known, such as fruit flies and mice. Nematostella is the first animal among the cnidarians that can be used as an animal model.

According to Dr. Uri Gat of the Alexander Silberman Institute of Life Sciences at the Hebrew University, who is participating in establishing the new center and is the first to introduce the Nematostella animal model system into Israel, although the Nematostella is a very simple, ancient life form, it is rich in genes, many of which are in common with humans and which constitute earlier versions of parallel genes in humans.

"Nematostella allows us for the first time to find the ancestral genes to the important developmental pathways that are common to all animals, and thus to understand their role in the initial course of evolution, which may shed light on the function and importance of these genes in humans," explains Dr. Gat. "For example, the Cnidarians developed one of the first nervous systems in animals, so if we learn how it was created and how it functions we could have new tools for researching and understanding the nervous system in humans."

Unlike humans, Nematostella possess the rare ability to restore large parts of the body that have been damaged. According to Gat, research into the Nematostella will enable a deeper understanding of injury repair processes that are similar to processes in humans, thus contributing to the future development of new drugs that can speed wound healing in humans and the development of new innovations for rehabilitating damaged organs.

According to Dr. Tamar Lotan of the Leon H. Charney School of Marine Sciences at the University of Haifa, the center will investigate the active mechanism of the Nematostellas stingers to discover ways to prevent injuries from the sea anemones relative, the jellyfish. In addition, the University of Haifa is examining the possibility of using Nematostella as a living sensor that can alert humans to seawater contamination.

The Nematostella Research Center will be funded by the Israeli Ministry of Science and Technology and will be located at Bar-Ilan University because of its central geographic location between the three institutions. This center will be the first of its kind in the world as it will be a first national inter-university center for Nematostella research.

Dr. Oren Levy, a partner in the center and director of the Laboratory for Molecular Marine Ecology at Bar-Ilan University, where his team studies biological clocks in corals, believes that cooperation between academics allows for bringing together different resources and sharing active research in the field. "In many parts of the world there are modern centers which offer the research scientist the state-of-the-art equipment, space and knowledge to enable scientific breakthroughs. We are proud to be involved in the creation of such a center here. Without a doubt, in this way we can advance science in Israel."

Published by Globes [online], Israel business news - www.globes-online.com - on March 7, 2012

Copyright of Globes Publisher Itonut (1983) Ltd. 2012

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